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Cyst and host tissue concentrations of mebendazole in patients undergoing surgery for hydatid disease
Author(s) -
Braithwaite Peter A.,
Allan Robert J.,
Dawson Michael,
Watson Thomas R.,
Roberts Michael S.
Publication year - 1983
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1983.tb122534.x
Subject(s) - mebendazole , hydatid cyst , parasite hosting , host (biology) , surgery , medicine , drug , cyst , echinococcosis , disease , pathology , biology , pharmacology , ecology , world wide web , computer science
Mebendazole levels were assayed by high performance liquid chromatographic assay in plasma, host tissues, and hydatid material taken from four patients who underwent surgery for hydatid disease. The drug was absorbed and had penetrated both into the host and into the parasite material. The levels of the drug in viable hydatid cysts were much lower than those in dead cysts. The possibility of exclusion or detoxification of the drug by viable hydatid cysts is raised.