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Response of the box‐jellyfish (Chfronex fleckeri) cardiotoxin to intravenous administration of verapamil
Author(s) -
Burnett Joseph W.,
Calton Gary J.
Publication year - 1983
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1983.tb122404.x
Subject(s) - verapamil , cardiotoxin , venom , jellyfish , pharmacology , antagonist , medicine , anesthesia , calcium , biology , fishery , receptor
Verapamil, a calcium antagonist, has been shown to be effective in delaying death in mice after intravenous challenge with box‐jellyfish (Chironex fleckeri) venom. Death from a challenge of up to three mouse‐lethal doses of venom was significantly delayed after the prior intravenous administration of verapamil (P = 0.003). A smaller dose of verapamil could “rescue” mice previously envenomed with 1.25 mouse‐lethal doses (P = 0.0001). These data suggest tht verapamil injections should be added to the first‐aid procedures performed on the beach for victims of box‐ jellyfish stings.