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Comparison of cinoxacin and co‐trimoxazole in the treatment of urinary tract infections
Author(s) -
Jersey Peter,
Wooller Harry O.
Publication year - 1982
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1982.tb132296.x
Subject(s) - urinary system , trimethoprim , medicine , sulfamethoxazole , adverse effect , urine , antibacterial agent , clinical trial , antibiotics , gastroenterology , microbiology and biotechnology , biology
A randomised single‐blind clinical trial compared cinoxacin (500 mg every 12 hours) to co‐trimoxazole (160 mg trimethoprim, 800 mg sulphamethoxazole every 12 hours) in the treatment of 63 patients with urinary tract infections. The symptomatic response was 73% for both drugs. Bacterial eradication was achieved in 81% and 100% of patients receiving cinoxacin and co‐ trimoxazole respectively. Three patients receiving co‐trimoxazole stopped treatment because of adverse reactions. We conclude that cinoxacin is an effective and safe antibacterial agent in the treatment of urinary tract infections.