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Colloidal bismuth subcitrate tablets and placebo in chronic duodenal ulceration
Author(s) -
Wilson Peter,
Alp Michael H.
Publication year - 1982
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1982.tb132277.x
Subject(s) - medicine , placebo , gastroenterology , bismuth , duodenal ulcer , clinical trial , pathology , materials science , alternative medicine , metallurgy
In a double‐blind, randomised trial of 46 outpatients with endoscopically proven chronic duodenal ulceration, 22 were given colloidal bismuth subcitrate (De‐Nol, Gist‐Brocades) and 24 were given placebo for four weeks. Clinical and laboratory assessment was made after two and (our weeks' therapy. Endoscopic healing was demonstrated in 86.5% of patients taking colloidal bismuth tablets and in 25% of patients taking placebo. We observed no clinical or biochemical side effects in either group. These results indicate that colloidal bismuth subcitrate tablets are well tolerated, and are effective in healing chronic duodenal ulcers.