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Metoprolol in hypertension
Author(s) -
Assaykeen Tatiana A.,
Micheli George
Publication year - 1982
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1982.tb132163.x
Subject(s) - metoprolol , medicine , tolerability , blood pressure , diuretic , anesthesia , diastole , population , cardiology , adverse effect , environmental health
We studied the efficacy and tolerability of metoproloi, administered alone or in combination therapy, in 703 hypertensive patients. We observed a significant decrease in both systolic and diastolic blood pressure in patients treated with metoproloi alone or with metoproloi and a diuretic. Of these, 60% to 85% achieved a diastolic blood pressure of 12 kPa (90 mmHg) or lower during the 12‐week trial. The maximum effect occurred after approximately three weeks. In the majority of patients, 100 mg twice a day controlled mild to moderate hypertension. Side effects (mainly gastrointestinal disturbances and dizziness) occurred in 15% of patients receiving metoproloi alone and led to treatment withdrawal in 6.7%. For the total patient population, these frequencies were 13.5% and 6.7% respectively , and decreased with time. Asthmatics and diabetics tolerated metoproloi extremely well, indicating the clinical importance of metoprolol's cardioselectivity.