Premium
METOCLOPRAMIDE: MANAGEMENT OF GASTROINTESTINAL INTOLERANCE IN RHEUMATOID ARTHRITIS PATIENTS
Author(s) -
Awerbuch Mark S.,
Milazzo Stephen C.,
Reiner Richard G.,
Alp Michael H.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb135743.x
Subject(s) - medicine , metoclopramide , rheumatoid arthritis , gastroenterology , arthritis , endoscopy , vomiting
Ten patients with rheumatoid arthritis who were unable to tolerate anti‐inflammatory doses of non‐steroidal anti‐inflammatory drugs (NSAIDs) were admitted to the study. After endoscopy three patients were taken out of the study because of frank gastric ulceration. Seven patients entered the six‐week study during which anti‐inflammatory doses of NSAIDs were preceded by 30 minutes by a 10‐mg dose of oral metoclopramide. The results of this pilot study suggest that pretreatment with metoclopramide enables patients with rheumatoid arthritis who have non‐ulcer dyspepsia to tolerate full dosage of NSAIDs.