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IN‐VITRO ACTIVITY OF ERYTHROMYCIN AGAINST ANAEROBIC MICROORGANISMS
Author(s) -
Harvey K. J.,
Miles H.,
Hurse A.,
Carson M.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb135740.x
Subject(s) - erythromycin , bacteroides fragilis , microorganism , microbiology and biotechnology , anaerobic exercise , in vitro , bacteroides , anaerobic bacteria , antibiotics , chemistry , bacteria , biology , pharmacology , biochemistry , physiology , genetics
Minimum inhibitory concentrations of erythromycin were determined, in the absence of CO 2 . for 256 strains of anaerobic microorganisms recently isolated from clinical practice. Of 126 strains of Bacteroides fragilis , 93% were inhibited by 6 mg/L, or less, of erythromycin. Of the remaining 130 isolates, 92% were inhibited by 6 mg/L, or less, of erythromycin. These findings suggest that the majority of anaerobic microorganisms would be inhibited by the serum levels achieved by administering 1 g of erythromycin, intravenously, every six hours.