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DETECTION OF AN IMMUNOSUPPRESSIVE FACTOR IN HUMAN PREIMPLANTATION EMBRYO CULTURES
Author(s) -
Cheng Y.,
Cripps Allan W.,
Clancy Robert L.,
Roberts Timothy K.,
Lopata Alexander,
Shutt Donald A.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb135326.x
Subject(s) - embryo , andrology , embryo transfer , oocyte , in vitro fertilisation , human fertilization , biology , pregnancy , embryo culture , in vitro , immunology , embryogenesis , microbiology and biotechnology , medicine , genetics
Within 48 hours of fertilization of human preovulatory oocytes in vitro , an immunosuppressive factor was detected in the culture medium by a rosette inhibition test. Cultures in which fertilization of the oocyte was unsuccessful were indistinguishable from control medium. Release of an early pregnancy factor from the preimplantation embryo could be of clinical significance to the establishment of pregnancy after embryo transfer.