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PHARMACOKINETICS OF PIPERACILLIN IN RENAL FAILURE
Author(s) -
George C. R. P.,
Burgoyne J.,
Funnell G. R.,
Robinson P.,
Collig P.,
Meads K.,
Guinness M. D. G.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb135286.x
Subject(s) - piperacillin , medicine , urine , pharmacokinetics , chronic renal failure , bolus (digestion) , urology , biology , genetics , bacteria , pseudomonas aeruginosa
Patients with chronic renal failure who received bolus doses of piperacillin maintained high serum levels for up to six hours. The percentage of the injected dose which was detectable in the urine in 24 hours was reduced proportionately to the severity of the renal failure.