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Interaction between ethanol and antihistamines: 3. mebhydrolin
Author(s) -
Franks Howard M.,
Lawrie Malcolm,
Schabinsky Val V.,
Starmer Graham A.,
Teo Richard K. C.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb112944.x
Subject(s) - ethanol , histamine , psychology , anesthesia , pharmacology , medicine , chemistry , biochemistry
We used 17 student volunteers in an experiment to investigate the effects of orally administered mebhydrolin (0.71 mg/kg), alone and in combination with ethanol (0.75 g/kg), on perceptual, cognitive and motor functions. Mebhydrolin did not significantly modify performance when given alone, but showed evidence of enhancing ethanol‐induced performance deficits. Histamine challenge experiments indicated that the dose of mebhydrolin used exerted an antihistaminic effect over the period of the ethanol interaction study.