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Oral bioavailability of theophylline from hydroalcoholic and alcohol‐free preparations
Author(s) -
Sligo Jennifer H.,
Charles Bruce G.,
Ravenscroft Peter J.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb101031.x
Subject(s) - theophylline , bioavailability , elixir (programming language) , pharmacology , oral administration , absorption (acoustics) , alcohol , chemistry , bronchodilator , medicine , biochemistry , asthma , materials science , computer science , composite material , programming language
We investigated the bioavailability of theophylline in eight healthy subjects following the oral administration of theophylline (128 mg) in hydroalcoholic (Brondecon elixir) and alcohol‐free (Nuelin syrup preparations. The trial was open, randomised and cross‐over. Theophylline was rapidly absorbed from both preparations. Bioavailability was assessed by measuring peak theophylline concentration, time to peak, absorption half‐lite and area under the curve. We concluded that the bioavailability of theophylline from each orally administered product was similar.