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Conjugated equine oestrogen versus placebo in the management of menopausal symptoms
Author(s) -
Hailes Jean D.,
Nelson Joy B.,
Schneider Melinda,
Rennie George C.,
Burger Henry G.
Publication year - 1981
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1981.tb100994.x
Subject(s) - placebo , medicine , regimen , crossover study , gynecology , menopause , estrogen , alternative medicine , pathology
One hundred women underwent a 10‐week sequential double‐blind/crossover to compare conjugated equine oestrogen (Premarin, 0.625 mg and 1.25 mg) with one and two placebo tablets in the management of menopausal symptoms. Sixty‐one subjects completed each of the four treatment regimens. Thirty‐one of these continued with their own choice of regimen for a further nine months. Premarin 1.25 mg proved to be significantly more effective (P<0.01) in ameliorating menopausal symptoms than Premarin 0.625 mg and both levels of placebo. Premarin 1.25 mg was also preferred as the treatment of choice by the 31 women ( P <0.001).