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Distribution of Complement C'2 and C'6 Types in Australian Cases of Diabetes Mellitus
Author(s) -
Kirk R. L.,
Ranford P. R.,
Court J.,
Zimmet P.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb77064.x
Subject(s) - diabetes mellitus , phenotype , complement (music) , disease , human leukocyte antigen , complement system , medicine , chromosome , insulin dependent diabetes , biology , immunology , endocrinology , genetics , autoimmune disease , antibody , antigen , gene , complementation
A series of patients with juvenile onset diabetes (IDDM) and mature onset diabetes (NIDDM) have been typed for genetic variants of two sets of complement factors. For the HLA–linked C'2 system, there was found a significant increase of the C'2 2‐1 type in IDDM compared with NIDDM patients or healthy controls. No such increase in any phenotype was observed for the non–HLA‐linked C'6 system. These observations emphasize again the genetic distinction between IDDM and NIDDM, and the role of chromosome 6 in controlling susceptibility to the insulin–dependent form of the disease.