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IRON OVERLOAD IN CONGENITAL ERYTHROCYTE PYRUVATE KINASE DEFICIENCY
Author(s) -
Salem H. H.,
Van Der Weyden M. B.,
Firkin B. G.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb135097.x
Subject(s) - pyruvate kinase deficiency , pyruvate kinase , medicine , endocrine system , endocrinology , excretion , metabolism , glycolysis , hormone
Severe iron overload developed in two patients with congenital erythrocyte pyruvate kinase deficiency. In one of them this was complicated by hepatic cirrhosis and endocrine dysfunction. In both patients, the institution of intermittent subcutaneous administration of desferrioxamine resulted in significant urinary iron excretion and a reduction in the degree of iron overload.