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COMPARISON OF PIRETANIDE AND CHLOROTHIAZIDE IN THE TREATMENT OF CARDIAC FAILURE *
Author(s) -
Gillies A.,
Morgan T.,
Myers J.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb134738.x
Subject(s) - chlorothiazide , diuresis , diuretic , medicine , heart failure , loop of henle , cardiac function curve , loop diuretic , cardiology , renal function , kidney , reabsorption
Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure. Over a three‐day period it caused a significant dose related diuresis and weight loss. It was as effective as chlorothiazide in the control of cardiac failure and was well tolerated by the patients. Potassium loss was less than occurred with chlorothiazide. Its role in the treatment of cardiac failure requires further study and warrants further investigation. The study also showed that many patients with cardiac failure receive diuretic drugs which are not necessary.