Premium
COMPARISON OF A SINGLE‐DOSE AND TWICE‐A‐DAY SPIRONOLACTONE THERAPY IN MILD HYPERTENSION
Author(s) -
Ludbrook A.,
Dy M.,
Mendelsohn F. A. O.,
Louis W. J.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb134686.x
Subject(s) - spironolactone , medicine , regimen , blood pressure , dosing , placebo , crossover study , essential hypertension , urology , cardiology , anesthesia , aldosterone , alternative medicine , pathology
Once‐a‐day therapy with spironolactone has been compared with a twice‐a‐day regimen in an open crossover trial in patients with essential hypertension. When compared with placebo, both treatments significantly lowered blood pressure. Twice‐a‐day therapy provided slightly better blood pressure control than the once‐a‐day dosing schedule. There were only minor differences in biochemical findings between the two regimens. Three of the 17 patients developed reversible gynaecomastia.