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COMPARATIVE BIOAVAILABILITY STUDY OF THEOPHYLLINE TABLETS MARKETED IN AUSTRALASIA
Author(s) -
Charles B. G.,
Ravenscroft P. J.,
Bochner F.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb131848.x
Subject(s) - theophylline , bioavailability , bioequivalence , absorption (acoustics) , pharmacology , bronchodilator , chemistry , plasma concentration , medicine , materials science , asthma , composite material
Average peak concentrations of theophylline in plasma (range, 15 μmol/L to 22 μmol/L) were not significantly different when Nuelin, Brondecon and Choledyl tablets were administered to healthy subjects. The fraction of the theophylline dose absorbed from these preparations was comparable (range, 0.82 to 0.90). In contrast, the absorption of theophylline was significantly different ( P <0.001) when the times to reach peak theophylline concentration were compared. Mean peak theophylline concentrations were achieved 1.5 hours after administration of either Neulin or Brondecon tablets and nine hours after Choledyl administration. Nuelin and Brondecon are considered to be bioequivalent. Choledyl may be used when side effects caused by rapid theophylline absorption are to be avoided.