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CORONARY SPASM MANAGEMENT WITH VERAPAMIL (ISOPTIN)
Author(s) -
Freedman Ben,
Richmond David R.,
Kelly David T.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb131806.x
Subject(s) - verapamil , isosorbide dinitrate , medicine , asymptomatic , angina , chest pain , cardiology , anesthesia , coronary arteries , artery , myocardial infarction , calcium
Because of recurrent chest pain, 17 patients with documented spasm in coronary arteries without severe atherosclerotic obstructions were treated with verapamil in an open trial, using doses of 120 mg/day to 480 mg/day (mean, 240 mg/day). Thirteen patients received additional oral isosorbide dinitrate (30 mg/day to 40 mg/day). Eleven patients became asymptomatic, and four experienced marked reduction in frequency of attacks (one to four a month). While two patients did not respond, in most patients verapamil was effective in preventing attacks of angina due to coronary spasm.