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INTERACTION BETWEEN PHENYTOIN AND VALPROATE
Author(s) -
Sansom L. N.,
Beran R. C.,
Schapel G. J.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb112200.x
Subject(s) - phenytoin , medicine , pharmacology , anticonvulsant , epilepsy , psychiatry
Displacement of Phenytoin from plasma proteins by valproate causes a reduction in total serum Phenytoin levels. However, no adjustment of Phenytoin dosage is warranted, unless clinically indicated, since the free Phenytoin levels remain unchanged.