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COPROANTIBODY RESPONSE TO ROTAVIRUS INFECTION
Author(s) -
Sonza Secondo,
Holmes Ian H.
Publication year - 1980
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1980.tb100710.x
Subject(s) - rotavirus , outbreak , antibody , rotavirus infections , medicine , immunology , immunoglobulin g , virology , feces , antibody response , virus , biology , microbiology and biotechnology
During three months after a family outbreak of diarrhoeal disease, rotavirus‐specific immunoglobulins of the IgA, IgG and IgM classes were measured by enzyme‐linked immunosorbent assay in faecal extracts from the four people involved. Shortly afterwards, sequential extracts were obtained from another infant after a proven rotavirus infection. Rotavirus infection was diagnosed by electron microscopy in three of the patients from whom acute‐phase faecal samples were obtained, and all five patients developed a transient specific‐antibody response. Antirotaviral IgA, IgM and IgG all reached peak titres between two and four weeks after infection, then dropped back to undetectable levels after two months. If these findings are confirmed in larger numbers of cases, they will provide the basis for simple diagnosis of recent rotavirus infections, without the need of even a single sample of serum.