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COMPARISON OF ENTERIC‐COATED LEVODOPA WITH LEVODOPA–CARBIDOPA COMBINATION
Author(s) -
Gilligan Bernard,
Wodak Jack,
Stark Richard,
O'Halloran Michael
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb142049.x
Subject(s) - levodopa , carbidopa , dose , crossover study , medicine , parkinson's disease , pharmacology , disease , placebo , pathology , alternative medicine
Twenty‐seven patients with idiopathic Parkinson's disease completed a double‐blind crossover trial which compared enteric‐coated levodopa (Prodopa) with levodopa–carbidopa combination (Sinemet). It was easy to stabilize the patients’ condition with either drug, and the dose‐sparing effect both of the enteric‐coated preparation, and of the levodopa–carbidopa combination was again noted. At the dosages used, the levodopa–carbidopa combination was objectively shown to be more effective in 71% of the patients investigated, although there was no clear personal preference for either preparation when patients compared the two parts of the trial. Both drugs play a valuable role in the treatment of Parkinson's disease.