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ABNORMAL FACTOR VIII IN CHRONIC RENAL FAILURE
Author(s) -
Howard Margaret A.,
Whitworth Judith A.,
Hendrix Lyne E.,
Thomas Kathrin B.,
Firkin Barry G.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb128950.x
Subject(s) - medicine , chronic renal failure , chronic renal disease , von willebrand factor , gastroenterology , disease , renal function , endocrinology , platelet
Factor vm procoagulant activity (vm‐C), related antigen (vm‐AG), and von Willebrand factor (vin‐vWf) were measured in 38 patients with chronic renal failure (CRF), in 19 patients with normal renal function from a general medical ward, and in 17 normal subjects. Wide variation in the levels of factor vm (fviii) functions were found in the group of CRF patients. There was no correlation between the levels of the three individual activities of fviii in renal disease. The levels of the three functions were elevated in the patient controls and no significant differences were found between the two groups of patients, although both groups were significantly different from the normal subjects. Increased electrophoretic mobility (EM) was detected in 22 of the 38 patients with CRF (58%) compared to seven of the 19 patient controls (37%). These studies suggest caution in interpretation of changes in fviii status in patients with other clinical disorders, such as liver disease.