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LABETALOL AND BENDROFLUAZIDE: comparison of their antihypertensive effects
Author(s) -
Horvath John S.,
Caterson Robyn J.,
Collett Paul,
Duggin Geoffrey G.,
Kelly Douglas H.,
Tiller David J.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb119425.x
Subject(s) - labetalol , blood pressure , crossover study , placebo , medicine , anesthesia , pharmacology , alternative medicine , pathology
A randomized, double‐blind crossover trial of labetalol, bendrofluazide and placebo was carried out in 18 patients with mild to moderate hypertension. The reduction in blood pressure observed with labetalol and bendrofluazide was similar. The plasma levels of labetalol showed a significant correlation with changes in blood pressure (r = 0.07; P < 0.021); and plasma level determinations of this drug may be of value in the management of patients who receive antihypertensive agents.