Premium
PREVENTION OF DUODENAL ULCER RELAPSE BY CIMETIDINE: A ONE‐YEAR DOUBLE‐BUND TRIAL
Author(s) -
Hetzel D. J.,
Shearman D. J. C.,
Hecker R.,
Sheers R.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb119377.x
Subject(s) - cimetidine , medicine , placebo , asymptomatic , endoscopy , duodenal ulcer , gastroenterology , clinical trial , surgery , pathology , alternative medicine
Fifty‐one patients with duodenal ulcer which was healed by a six‐week course of Cimetidine completed a one‐year double‐blind study to compare the effects of Cimetidine and placebo on the prevention of ulcer relapse. Patients were allocated at random to receive either 400 mg of Cimetidine twice daily or placebo. Ulcer relapse was assessed by regular clinical follow up and endoscopy. A total of six of the 24 cimetidine‐treated patients (25%) suffered a relapse compared to 25 of the 27 of placebo‐treated patients (92.6%). Out of this total number of relapses, asymptomatic relapse with ulceration discovered by routine endoscopy at six months or one year, occurred in three patients receiving Cimetidine and eight patients receiving placebo. Cimetidine prevents recurrence in patients with duodenal ulcer disease.