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THE COURSE OF UNTREATED MILD T 3 TOXICOSIS
Author(s) -
Stockigt J. R.,
White E. L,
Petrou S.,
Taft P.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb112645.x
Subject(s) - medicine , persistence (discontinuity) , spontaneous remission , hormone , adenoma , adverse effect , gastroenterology , endocrinology , physiology , pathology , alternative medicine , geotechnical engineering , engineering
A selected group of 12 patients with mild T 3 toxicosis, has been assessed without treatment during a period of from seven to 38 months. Progression to typical hyperthyroidism with combined T 4 and T 3 excess occurred in one case of solitary toxic adenoma, while a spontaneous remission with return of the thyrotropin response to thyrotropin‐releasing hormone occurred in one patient with a diffuse goitre. The other 10 patients showed persistence of isolated high levels of T 3 without clinical or biochemical progression. These findings suggest that progression to typical hyperthyroidism is infrequent in mild T 3 toxicosis. Because of the possible adverse effects of therapy it may be appropriate to observe, rather than treat, some patients with mild clinical and biochemical features of hyperthyroidism.