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DIAZINON AND PORPHYRIA CUTANEA TARDA
Author(s) -
Bleakley Pamela,
Nichol A. W.,
Collins A. G.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb112123.x
Subject(s) - porphyria cutanea tarda , diazinon , porphyrin , porphyria , medicine , detoxification (alternative medicine) , feces , oral administration , physiology , chemistry , dermatology , endocrinology , biology , pathology , biochemistry , pesticide , microbiology and biotechnology , alternative medicine , agronomy
Cutaneous application of diazinon to rats over a period of 12 weeks gives rise to a condition biochemically indistinguishable from porphyria cutanea tarda. Faecal porphyrin levels are elevated with the appearance of isocoproporphyrin in the faeces. Oral administration of diazinon does not appear to cause any disturbance of porphyrin metabolism.