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URINARY FERRITIN PROTEIN IN SUBJECTS WITH PROSTHETIC HEART VALVES AND OTHER DISORDERS
Author(s) -
Abbott Richard L.,
Blunden Robert W.,
Kimber Richard J.,
McPhie John M.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb112118.x
Subject(s) - urine , lactic dehydrogenase , haemolysis , excretion , medicine , urinary system , red cell , lactate dehydrogenase , ferritin , hemoglobin , gastroenterology , endocrinology , biology , biochemistry , immunology , enzyme
Twenty‐four‐hour urine ferritin protein excretion (ufpe) was elevated in the great majority of patients with prosthetic cardiac valves. In this group, there was a positive correlation with the presence of haemosiderin in the urine and with another indirect measure of reduced red‐cell survival, namely, serum lactic dehydrogenase. In a number of hospital patients with various disorders, ufpe was also increased. In this latter group, however, there was no constant accompanying haemosiderinuria or elevation of lactic dehydrogenase. The measurement of ufpe can be added to the list of screening tests for intravascular haemolysis, but analysis of the different isoferritins in urine is necessary to fully understand the mechanism of excretion in the different groups.