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TINIDAZOLE IN THE PREVENTION OF WOUND INFECTION AFTER ELECTIVE COLORECTAL SURGERY
Author(s) -
Hunt P. S.,
Francis J. K.,
Peck G.,
Farrell K.,
Sali A.
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb112039.x
Subject(s) - tinidazole , medicine , placebo , surgery , colorectal surgery , wound infection , clinical endpoint , randomized controlled trial , wound healing , surgical wound , anesthesia , metronidazole , antibiotics , abdominal surgery , alternative medicine , microbiology and biotechnology , biology , pathology
During the first six months of 1978, 71 patients were the subject of a controlled trial of the use of tinidazole for the prevention of wound infection after elective colonic surgery. The trial design was prospective, randomized and double‐blind with tinidazole or placebo given at the last oral intake before operation. The objective endpoint of the trial was the presence or absence of wound infection manifested by pus. All patients underwent a standard preoperative preparation of bowel washouts, and a standardized surgical technique included, in all cases, the use of wound drainage. At the end of the trial there were three wound infections in 40 patients who were given tinidazole, and eleven wound infections in 31 patients who were given placebo. The difference in wound infection rate between these two groups is significant (χ 2 with Yates correction=7.3; P <0.01).