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HYDRALLAZINE WITH BETA‐BLOCKER AND DIURETIC IN THE TREATMENT OF HYPERTENSION: A DOUBLE‐BLIND CROSSOVER STUDY
Author(s) -
M.B S. Kalowski,
Hua A. S. P.,
Whitworth Juditha,
KincaidSmith Priscilla
Publication year - 1979
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1979.tb104254.x
Subject(s) - diuretic , crossover study , medicine , beta (programming language) , crossover , beta blocker , cardiology , heart failure , alternative medicine , pathology , placebo , artificial intelligence , computer science , programming language
Thirty‐seven hypertensive patients were treated with cyclopenthiazide, Oxprenolol and hydrallazine. Blood pressure was controlled in 31 patients and a subsequent double‐blind crossover study in 27 patients comparing hydralazine with placebo confirmed the efficacy of hydralazine in combination with diuretic and β‐adrenergic‐blocking agent. The combination was effective in patients with renal hypertension and renal impairment. No adverse effects on renal function were observed. Patients who were slow acetylators had significantly better blood pressure control and more side effects. In view of the frequency of hydralazine related side effects, prior institution of β‐adrenergic blocking drugs is desirable.