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Extensive Damage to Substantia Nigra in Chronic Alcoholics
Author(s) -
Kariks J.
Publication year - 1978
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1978.tb131792.x
Subject(s) - substantia nigra , eosinophilic , melanin , chronic alcoholism , depigmentation , pathology , chronic alcoholic , medicine , neuroscience , dopamine , biology , dopaminergic , dermatology , genetics
Neuronal depigmentation, necrosis, and increased pigment (melanin) and iron depositions in the perivascular spaces have been observed in the substantia nigra in chronic alcoholics. Eosinophilic nuclear inclusions, the significance of which remains unclear, were noted with an increased frequency within the nuclei of the substantia nigra neurons.