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A Comparison of Controlled Pore Glass Chromatography and Ultra Centrifugation for Detecting Igm Antibody in Congenital Rubella Infection
Author(s) -
Robertson P. W.,
Giannikos J.,
Bishop G. A.
Publication year - 1978
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1978.tb131552.x
Subject(s) - rubella , congenital rubella , medicine , antibody , cord blood , rubella virus , immunology , immunoglobulin m , centrifugation , chromatography , virology , immunoglobulin g , chemistry , measles , vaccination
Screening programmes for inapparent congenital rubella infection have created a need for accurate methods of laboratory diagnosis of this disease in the newborn. Demonstration of rubella‐specific immunoglobulin M (IgM) antibody in either cord blood or neonatal serum is accepted as the most convenient method available. This study reports a chromatographic method with Controlled Pore Glass for demonstrating rubella‐specific IgM antibody. The technique is more practical for use in the diagnostic laboratory than other currently advocated methods of serum separation and is at least as sensitive.