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A COMPARISON BETWEEN SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE WITH AND WITHOUT α‐METHYLDOPA IN THE TREATMENT OF HYPERTENSION
Author(s) -
Walter N. M. A.,
Suthers M. B.,
Friedman A.,
Johnston C. I.
Publication year - 1978
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1978.tb112590.x
Subject(s) - hydrochlorothiazide , spironolactone , methyldopa , medicine , blood pressure , essential hypertension , crossover study , diuretic , pharmacology , plasma renin activity , urology , renin–angiotensin system , placebo , aldosterone , alternative medicine , pathology
In a single blind crossover trial, spironolactone (50 mg twice a day), and hydrochlorothiazide (50 mg twice a day) were equally effective hypotensive agents in 16 patients with untreated essential hypertension. The addition of α‐methyldopa (250 mg three times a day) to each agent produced a further significant and equal fall in blood pressure. Spironolactone therapy was associated with fewer clinical and biochemical side effects. The hypotensive effect of the diuretics was independent of the renin status of the patients.