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RESULTS FROM A MULTICENTRE TRIAL OF METOPROLOL AND A STUDY OF HYPERTENSIVE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE
Author(s) -
Hua Andrew S. P.,
Assaykeen Tatiana A.,
Nyberg Gunnar,
KincaidSmith Priscilla S.
Publication year - 1978
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1978.tb112549.x
Subject(s) - metoprolol , medicine , bronchospasm , blood pressure , concomitant , asthma , cardiology , obstructive lung disease , heart rate , anesthesia , exacerbation , copd
Ninety‐nine patients took part in a multicentre, long‐term study of metoprolol in the treatment of hypertension. Significant reductions in blood pressure and heart rate were achieved by the use of metoprolol alone, or in combination with other antihypertensive agents. Side effects were similar to those seen with other β–adrenergic blocking agents, except that bronchospasm and cold extremities were rarely encountered. Results of monitoring for the abnormal eye symptoms and antinuclear factor titre are discussed. In a second study, 14 hypertensive patients with asthma (11 patients) or history thereof (three patients), received metoprolol for their hypertension. In general, no significant change in forced expiratory volume in one second (FEV 1 ) was found, despite significant reduction in blood pressure and heart rate. The concomitant use of a β 2 ‐agonist is discussed.