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PHENACETIN AND ANALGESIC NEPHROPATHY
Author(s) -
Burry Alastair,
Hopkins Janet
Publication year - 1977
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1977.tb131210.x
Subject(s) - phenacetin , medicine , analgesic , incidence (geometry) , nephropathy , anesthesia , pharmacology , endocrinology , physics , optics , diabetes mellitus
A prospective survey of 322 autopsies of adults conducted some months after phenacetin was removed from a popular compound analgesic showed no reduction in the incidence of advanced or earlier forms of analgesic nephropathy from levels noted in an earlier survey. Apparently active nephropathy was seen in persons taking two different compound analgesics, neither now containing phenacetin. Crystals observed in early and intermediate analgesic nephropathy had no diagnostic significance and represented a tissue breakdown product.