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A SEQUENTIAL TRIAL OF VILOXAZINE (VIVALAN) AND IMIPRAMINE IN MODERATELY DEPRESSED PATIENTS
Author(s) -
Davies Brian,
Joshua Stephen,
Burrows Graham,
Poynton Carol
Publication year - 1977
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1977.tb130866.x
Subject(s) - imipramine , depression (economics) , medicine , rating scale , significant difference , psychology , developmental psychology , alternative medicine , pathology , economics , macroeconomics
Patients with moderately severe depressive illness were matched for age, sex, severity of symptoms and number of previous episodes of affective illness. Eleven pairs of patients were randomly assigned to four weeks' treatment with either viloxazine (100 mg three times a day) or imipramine (50 mg three times a day). Both treatments were associated with significant reductions in the scores on depression rating scales. With a sequential testing plan based on repeated significance tests and formed into a skewed restricted plan, no difference in the two treatments was shown. Significantly fewer side effects were reported by patients receiving viloxazine.