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LACTULOSE IN VINCRISTINE‐INDUCED CONSTIPATION
Author(s) -
Harris Arthur C.,
Jackson J. Muir
Publication year - 1977
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1977.tb114646.x
Subject(s) - lactulose , vincristine , constipation , medicine , refractory (planetary science) , gastroenterology , anesthesia , chemotherapy , cyclophosphamide , physics , astrobiology
Constipation which is resistant to the usual range of laxatives is a troublesome undesirable effect of vincristine. Lactulose in doses up to 25 ml thrice daily proved to be a simple and effective treatment in six patients with refractory vincristine‐induced constipation, and a successful prophylactic in two other patients. Palatable, and without any serious undesirable effects, lactulose can improve the quality of life for patients with a malignant tumour which is responsive to vincristine.