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TOBRAMYCIN IN THE TREATMENT OF SEVERE AND COMPLICATED URINARY TRACT INFECTIONS
Author(s) -
Bailey Ross R.,
Peddie Barbara
Publication year - 1977
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1977.tb113917.x
Subject(s) - tobramycin , aminoglycoside , medicine , gentamicin , antibiotics , urinary system , pseudomonas aeruginosa , sepsis , intensive care medicine , microbiology and biotechnology , bacteria , biology , genetics
Tobramycin is an aminoglycoside aminocyclitol antibiotic with pharmacological similarities to gentamicin. Twenty‐one of 30 patients with a severe or complicated Gram‐negative urinary tract infection were cured by treatment with a 5‐day course of tobramycin. No side effects were noted. This drug should prove beneficial for the treatment of severe Gram‐negative sepsis, and promises to be particularly valuable for infections due to Pseudomonas aeruginosa . Dosage schedules for administering tobramycin to patients with renal function impairment are presented, together with some observations on its intravenous injection by bolus. A single dose of tobramycin has proved effective for initiating the antibacterial treatment of patients with acute pyelonephritis. The important concept of the differing concentrations of an antibiotic in the urine from kidneys of unequal function is discussed.