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MEDULLARY CARCINOMA OF THE THYROID, MULTIPLE PHAEOCHROMOCYTOMAS, MUCOSAL NEUROMAS, MARFANOID HABITUS AND OTHER ABNORMALITIES (SIPPLE'S SYNDROME)
Author(s) -
Bartley Paul C.,
Lloyd H. M.,
Aitken R. E.
Publication year - 1976
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1976.tb134453.x
Subject(s) - medicine , medullary carcinoma , calcitonin , medullary cavity , thyroid , endocrinology , neuroma , thyroidectomy , thyroid carcinoma , pathology , surgery
A case of Sipple's syndrome is reported, in which the full phenotype was expressed. The patient had the typical marfanoid habitus, with thickened lips and alae nasi, neuromas on lips and tongue, medullary carcinoma of the thyroid gland, phaeochromocytomas, and medullated corneal nerve fibres. The plasma calcitonin level was initially elevated, rose on calcium infusion before thyroidectomy, and was undetectable after thyroidectomy. The urinary catecholamine excretion was elevated. The plasma parathyroid hormone, adrenocorticotrophin and growth hormone levels and the serum calcium level were normal.