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A CONTROLLED TRIAL OF INTRAVENOUS SALBUTAMOL AND AMINOPHYLLINE IN ACUTE ASTHMA
Author(s) -
Tribe A. E.,
Wong R. M.,
Robinson J. S.
Publication year - 1976
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1976.tb128275.x
Subject(s) - aminophylline , salbutamol , medicine , anesthesia , asthma , heart rate , pulse rate , blood pressure
In a randomized double‐blind trial an intravenous injection of salbutamol (100 μg) was compared with an intravenous injection of aminophylline (250 mg) in 23 patients with acute exacerbations of asthma. Salbutamol (11 cases) and aminophylline (12 cases) produced a mean proportionate increase in FEV 1 of 26% and 23% respectively. Blood gas pressures showed a trend to improvement with a mean rise in oxygen tension of 2 mm Hg (0·2 kPa) in the aminophylline group and of 6 mm Hg (0·8 kPa) in the salbutamol group. Electrocardiogram patterns also showed overall improvement, and mean decreases in pulse rate of 8 beats per minute and 2 beats per minute were noted in the aminophylline and salbutamol groups respectively. Differences in results did not reach conventional levels of significance and no serious side effects were noted. It was concluded that, in the doses and routes of administration compared, salbutamol was as effective as aminophylline.