Premium
KLINEFELTER'S SYNDROME: EXPERIENCES WITH 24 PATIENTS
Author(s) -
Humphery T. J.,
Posen S.,
Casey J. H.
Publication year - 1976
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1976.tb115353.x
Subject(s) - klinefelter syndrome , psychosocial , gynecomastia , androgen deficiency , medicine , androgen , endocrinology , androgen insensitivity syndrome , personality , pediatrics , physiology , psychology , psychiatry , hormone , androgen receptor , social psychology , prostate cancer , cancer
Twenty‐four karotypically proven patients with Klinefelter's syndrome were studied. The majority suffered from disorders of personality and social adjustment. All were poorly educated. Two‐thirds showed gynaecomastia and all had small testes. Eunuchoid body proportions were seen in the majority of patients. Half the patients had plasma androgen levels in the low normal range; in the rest the levels were subnormal. The serum LH level was elevated in 80% and could not be adequately suppressed by exogenous androgens in seven out of nine patients. Abnormalities of carbohydrate metabolism were demonstrated in seven patients. Bilateral mastectomy was a valuable form of therapy, but androgens were withheld for psychosocial reasons.