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ACTINOMYCIN D IN THE TREATMENT OF PAGET'S DISEASE OF BONE
Author(s) -
SOMERVILLE PETER J.,
EVANS RICHARD A.
Publication year - 1975
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1975.tb95071.x
Subject(s) - paget's disease of bone , disease , medicine , side effect (computer science) , bone pain , gastroenterology , surgery , computer science , programming language
Fifteen patients with Paget's disease of bone were treated with actinomycin D for periods of up to 15 months. It was found that actinomycin D is effective in reducing the pain but not the neurological effects of Paget's disease. Careful adjustment of dose according to weight and initial response is necessary to prevent gastrointestinal side effects. If this is done, the risk of hepatic, renal, or haematological side effects is negligible.