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COMPARISON OF A NEW ANORECTIC AGENT AN 448 WITH FENFLURAMINE IN THE TREATMENT OF REFRACTORY OBESITY
Author(s) -
Goldrick R. Brian,
Nestel Paul J.,
Havenstein Nathalie
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb93399.x
Subject(s) - anorectic , fenfluramine , refractory (planetary science) , medicine , crossover study , dexfenfluramine , obesity , limiting , pharmacology , body weight , serotonin , biology , receptor , astrobiology , mechanical engineering , alternative medicine , pathology , engineering , placebo
The efficacy and safety of a new synthetic tricyclic anorectic agent, AN 448, were tested against fenfluramine in a single‐blind crossover trial on 22 severely obese patients. AN 448 exhibited an equivalent anorectic effect to that of fenfluramine. Both drugs were well tolerated and caused no serious side effects. However, a progressive resistance developed to the anorectic effects of AN 448 and fenfluramine so limiting their long‐term usefulness in the treatment of refractory obesity.