Premium
MINOCYCLINE IN SINGLE DOSE THERAPY IN THE TREATMENT OF GONOCOCCAL URETHRITIS IN MALE PATIENTS
Author(s) -
Baytch H.
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb93368.x
Subject(s) - minocycline , medicine , urethritis , cure rate , penicillin , urethra , gonorrhea , chlamydia , surgery , antibiotics , family medicine , human immunodeficiency virus (hiv) , microbiology and biotechnology , biology , immunology
Fifty males with uncomplicated gonorrhœa were allocated for treatment with 300 mg of minocycline. Cure rate, as judged by the absence of gonococci from a urethral smear and a negative culture from the urethra at 21 days, was 46% of those who commenced the trial, or 62% of those from whom we have a true history up until the twenty‐first day. If one accepts the history given by the three traced defaulters as being accurate then the minimum known cure rate rises to 52%. On the basis of those who completed the trial, 62% were cured. In this trial, the author did not manage to obtain the high percentage cure rate obtained by other clinicians. Nevertheless, the drug tested is of value for penicillin‐allergic patients, for patients likely to default, and for transients such as sailors, interstate travellers and interstate long distance drivers. A point of favourable comment is also the low degree of toxicity as evidenced by the extremely few, and minor nature of, side effects reported by the patients.