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IN‐VITRO LEUCOCYTE MIGRATION IN RENAL TRANSPLANTATION *
Author(s) -
Green Marjorie K.,
Clunie Gordon J. A.
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb93295.x
Subject(s) - medicine , in vitro , cadaveric spasm , transplantation , renal transplant , immunology , gastroenterology , surgery , biology , biochemistry
A series of control studies in normal persons and patients undergoing a variety of operative procedures has established a normal range for in‐vitro leucocyte migration. In a series of 20 recipients of cadaveric renal allografts, 15 patients showed inhibition of leucocyte migration one to four days before changes in renal function resulting from rejection. Early treatment with high doses of steroids and external irradiation on the basis of inhibition of migration resulted In better control of rejection crises than when treatment was delayed until biochemical changes had occurred. In the remaining five patients, there was no variation in leucocyte migration outside the normal range, and none of these patients showed rejection. We conclude that the test is of value in the management of patients after renal transplantation, not only in the early detection and management of rejection crises, but also in minimizing immunosuppressive drug dosage in those patients showing no evidence of inhibition of migration.