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DISSOLUTION OF DIGOXIN TABLETS
Author(s) -
Ng Kingsley,
McCredie R. M.
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb93255.x
Subject(s) - digoxin , dissolution , hydrochloric acid , chemistry , significant difference , pharmacology , chromatography , medicine , inorganic chemistry , heart failure
The dissolution rate of seven different brands of digoxin tablets was studied. The amount of digoxin dissolved in 0·6% hydrochloric acid at 37.C was expressed as a percentage of the amount available for solution. There was considerable variation between brands, from 28·7 p SD 2·30% for brand G to 98·3 p SD 3·24% for brand A after 60 minutes. For all brands 95% of the dissolution at 60 minutes had occurred by 30 minutes. These dissolution rates correlated closely with plasma levels found in normal subjects in the first seven hours after an oral dose of the same brands of digoxin and suggest that a difference in dissolution rates between different brands of digoxin is an important determinant of biological availability of the drug.