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EVALUATION OF THE NATIVE DNA‐BINDING ASSAY FOR DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER CONNECTIVE TISSUE DISEASES
Author(s) -
Webb John,
Whaley Keith
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb70809.x
Subject(s) - anti nuclear antibody , antibody , dna , connective tissue , immunology , connective tissue disease , disease , lupus erythematosus , medicine , systemic disease , antigen , homogeneous , autoimmune disease , biology , pathology , autoantibody , biochemistry , physics , thermodynamics
The serum DNA‐binding assay technique has been used to examine sera from patients with a variety of connective tissue diseases for antibodies to native DNA. Serum native DNA‐binding values exceeding 30% were found almost exclusively in patients with active systemic lupus erythematosus, and correlated with the presence of a homogeneous pattern of antinuclear factor in titres of 1 in 256 or greater, and the technique is of obvious clinical importance in the diagnosis of this disease. In addition, serum native DNA antigen‐binding capacity alterations, especially during the early weeks following institution of therapy for this disease, appear to offer good prognostic and therapeutic guidelines for management.