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CONGENITAL CHOROIDO‐RETINITIS AND CEREBRAL DAMAGE FROM UNIDENTIFIED INFECTIVE AGENTS
Author(s) -
Keith C. G.
Publication year - 1974
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1974.tb50786.x
Subject(s) - toxoplasmosis , hydrocephalus , retinitis , medicine , brain damage , syphilis , rubella , cytomegalovirus , differential diagnosis , calcification , toxoplasma gondii , pathology , pediatrics , dermatology , immunology , surgery , measles , herpesviridae , human cytomegalovirus , virus , viral disease , human immunodeficiency virus (hiv) , antibody , vaccination
The cases of five children with congenital choroidoretinal scarring and cerebral damage are described. Three had hydrocephalus, one microcephalus and one convulsions. The clinical pictures were consistent with toxoplasmosis except for the absence of intracranial calcification and the negative dye test result. Twenty similar cases were described by Sabin and Feldman in 1949. The differential diagnosis is discussed in relation to the other known causes of congenital eye and brain damage, such as rubella, cytomegalovirus, Herpesvirus hominis, and syphilis. Since cases have been described in which the dye test result was negative, yet toxoplasma were cultured from eyes suffering from uveitis, it is considered possible that these five cases could still have been a result of toxoplasma infection.