Premium
INITIAL TREATMENT OF TUBERCULOSIS WITH RIFAMPICIN
Author(s) -
O'CONNELL J.,
Campbell A. H.,
Cowen K.,
Verins A.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb76612.x
Subject(s) - regimen , isoniazid , ethambutol , rifampicin , medicine , tuberculosis , streptomycin , sputum , surgery , antibiotics , pathology , microbiology and biotechnology , biology
A comparison has been made between two drug regimens in the initial treatment of cavitated pulmonary disease due to Mycobacterium tuberculosis. Regimen 1 consisted of rifampicin–isoniazid–ethambutol and regimen 2 of streptomycin–PAS–isoniazid; after three months or on bacteriological conversion, these were reduced to rifampicin–isoniazid and PAS–isoniazid. Twenty–five patients entered regimen 1 and 23 regimen 2. There were no significant differences between the groups in regard to age, sex or severity of disease as evidenced by X–ray examination. Regression analysis showed a significantly more rapid conversion of sputum cultures in regimen 1. Significantly ntore toxic effects were noted in regimen 2, eight patients needing to be withdrawn from this regimen as against one in regimen 1.