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A STUDY ON THE EFFECTS OF IBUPROFEN ON THE METABOLISM OF ANTIPYRINE IN MAN
Author(s) -
Lee Peter,
Bell Margaret A.,
Webb John,
Goh Victor,
Chalmers Ian M.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb76579.x
Subject(s) - ibuprofen , microsome , metabolism , drug metabolism , enzyme inducer , liver enzyme , pharmacology , chemistry , medicine , enzyme , endocrinology , biochemistry
The effect of ibuprofen on the half–life of anti–pyrine has been studied in 12 normal subjects. After taking ibuprofen in a daily dose of 1,200 mg for 14 days, there was no significant alteration in the mean half–life of antipyrine. It is concluded that ibuprofen has no significant effect on either the induction or inhibition of hepatic microsomal enzymes.