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PHENYLKETONURIA TESTING IN AUSTRALIA SEX RATIO
Author(s) -
Pitt David,
McFarlane Jean,
Francis Ivan,
Gaha T. J.,
Hill Geoffrey,
Crotty J. M.,
Masters Peter,
Cusick Edward
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb119699.x
Subject(s) - incidence (geometry) , pediatrics , medicine , phenylketonurias , demography , sex ratio , phenylalanine , biology , genetics , environmental health , population , physics , amino acid , sociology , optics
Among 69 cases of classical phenylketonuria (PKU) detected by Guthrie testing In Australia, there was a preponderance of males over females (43 :26, P<0 04). We have no explanation for these unexpected findings, which confirm the findings in the U.S.A. Collaborative Study on PKU, other than the previous suggestion that some females with slow‐rising phenylalanine levels are being missed by the current testing programmes. Further studies on the sex ratio of future retarded cases of PKU (missed by early testing) should test this hypothesis. The overall incidence of classical PKU In Australia is 1/10,805, but there are some curious differences, as yet unexplained, between rates in individual States.